Changelog

v0.4.0 — 2026-07-09 — "auditable research workbench + patent-brief"

• Automated review layer (Reviewer). /research now runs retrieve→resolve→design→reason→review→artifact. Verifies citation traceability, number consistency, and claim grounding → verdict PASS/WARN/FAIL. Claim-by-claim audit rendered in the chat frontend.
• Patent-brief product surface. evolrix.bio/patent-brief: bilingual landing + async job→PDF + lead form. Runs always-on on Aliyun.
• Research articles sorted newest-first; kairos-reviewer-layer case published with PubMed-verified references.

v0.3.0 — 2026-07-01 — "chat UX: clean reasoning + design-panel from a name"

• Clean reasoning stream. Strategy section shows structured dossier, not raw token stream. <think> tags stripped.
• Stale cache purge. Outdated conversations cleared from localStorage on load.
• Target-protein input. Send a protein name or UniProt accession to unlock the design panel (resolved via UniProt REST API).

v0.2.1 — 2026-07-01 — "target-protein resolution"

• UniProt name→sequence resolution. target_protein accepts a name or accession, resolves to a reviewed Swiss-Prot sequence. Unresolved → design skipped honestly, never fabricated.

v0.2.0 — 2026-07-01 — "host-faithful reward + clean reasoning"

• Host-aware retrieval rerank. Off-target evidence fixed (generic promoter query 0/6 → 4/6 on-target).
• Within-protein reward recalibration. CAI 0.45 + genome-LM 0.45. Within-protein real-titer ρ +0.169 → +0.314.
• Anti-hack host-fidelity guardrail. An E. coli-table optimizer can no longer beat honest Pichia (5/5).
• Host-fidelity ranker on the design panel. ρ +0.35 (~2.7× the old Pareto panel).
• U3 RL line closed as a rigorous null — durable value landed in the reward.

v0.1.0 — baseline — "explainable Pichia CDS design"

• Modular candidate-design stack: CDS validation, host-aware synonymous panels, manufacturability / host-likeness / 5′ initiation / developability scorecards, secretion signal-peptide fusion, research copilot (3-tier provenance), async job + SSE.